Bloody Minded Episode 10 - Snakes on the (Clinical) Brain | Venoms in Clinical Use with Dr Maeve Crowley
Jul 16, 2024
Dr. Maeve Crowley, a consultant hematologist from Cork University Hospital, shares her expertise in hemostasis and thrombosis, highlighting the fascinating role of snake venoms in clinical testing. She discusses the practical uses of snake venom assays, particularly in lupus anticoagulant testing, and tackles the complexities of anticoagulation challenges. The conversation also delves into treatment strategies for antiphospholipid syndrome, weighing traditional and novel therapies. Tune in for an enlightening journey from lab discoveries to their clinical applications!
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Maeve's Path to Hematology
- Maeve Crowley found her passion for hematology through hands-on lab work guided by an enthusiastic registrar.
- She enjoyed linking laboratory results directly to patient care and diagnoses such as TTP and acquired hemophilia.
Utility of DRVVT in Labs
- The Dilute Russell Viper Venom Time (DRVVT) is widely used for lupus anticoagulant screening due to its accuracy and reproducibility.
- Its diagnostic utility stems from factor X activation, making it suitable even for less specialized laboratories.
Ensure Proper Lupus Anticoagulant Testing
- Ensure appropriate patient selection and pre-test conditions to improve lupus anticoagulant test accuracy.
- Obtain full clinical information, especially anticoagulation status, to avoid indeterminate or misleading results.