1) Neurology® Clinical Practice: Clinical Exome Sequencing in Neurologic Disease 2) What's Trending: Interview with Natalia del Campo about her paper on relationship of regional brain beta-amyloid to gait speed3) Topic of the month: Neurology Today story about pioglitazone found to be associated with a lower risk of secondary stroke in Non-diabetic patients with insulin resistanceThis podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Ted Burns interviews Dr. Brent Fogel about his Neurology: Clinical Practice paper on clinical exome sequencing in neurologic disease. Dr. Ted Burns is interviewing Dr. Natalia del Campo for our "What's Trending" feature of the week about her paper on relationship of regional brain beta-amyloid to gait speed. Dr. Andy Southerland interviews Dr. Walter Kernan about a Neurology Today story on the topic of pioglitazone found to be associated with a lower risk of secondary stroke in Non-diabetic patients with insulin resistance.DISCLOSURES: Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc.Dr. Fogel received speaker honoraria from the American Academy of Neurology and American Physician Institute for Advanced Professional Studies; received funding for travel from American Physician Institute for Advanced Professional Studies and National Ataxia Foundation; receives research support from American Physician Institute for Advance Professional Studies, National Ataxia Foundation and the NIH.Dr. Southerland serves as Podcast Deputy Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: "Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;" and gave legal expert review.Dr. Kernan academic institution receives research support from Takeda Pharmaceutical Company Limited and the NIH.NO CME WILL BE OFFERED THIS WEEK.