Bloody Minded Episode 1 - Crafting a Clot | Coagulation Cascade Overview
May 14, 2024
Join the hosts as they unravel the fascinating complexities of the coagulation cascade. Discover how each factor plays a vital role in clot formation, with a surprising twist on traditional teachings. The discussion moves from the misunderstood classical model to a more accurate cellular model, shedding light on its implications for clinical practice. Unearth the critical involvement of platelets and how medications can influence clotting processes differently. It's an engaging dive into the world of hematology that challenges preconceived notions!
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Coagulation Cascade As Y Pathway
- The coagulation cascade can be visualized as a Y with three parts: intrinsic, extrinsic, and common pathways. - The intrinsic and extrinsic pathways activate the common pathway, which produces fibrin to form a clot.
Cascade Amplifies And Regulates Clotting
- The cascade amplifies a small trigger to produce a large fibrin clot quickly and allows regulation at multiple steps. - This prevents continuous clotting that could use up clotting resources and cause problems.
Fibrinogen Turns Into Fibrin
- Fibrinogen (factor 1) circulates in an inactive form and is converted by thrombin (factor 2a) into fibrin to build a clot. - Broken down fibrin forms D-dimers which are markers used to detect clot formation.