Revolution Health Radio RHR: The Lipid Energy Model and Lean Mass Hyper Responders, with Dr. Nicholas Norwitz
Mar 6, 2024
Dr. Nicholas Norwitz, a PhD researcher in human metabolism and a Harvard Medical School MD student, shares his insights on the lipid energy model and lean mass hyper-responders. He discusses how individuals on low-carb diets can see increased LDL cholesterol while improving overall health, challenging traditional beliefs about cholesterol and cardiovascular risk. Dr. Norwitz also recounts his intriguing self-experiment with Oreos, emphasizing the need for personalized assessments in understanding lipid profiles and heart health.
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Extreme Personal LDL Shift And Oreo Test
- Nicholas Norwitz went from LDL-C 95 to 545 after adopting a low-carb ketogenic diet.
- He then added a sleeve of Oreo cookies and cut LDL-C by 71% within 16 days, exceeding statin effect in his N=1 test.
Mechanism Behind The Lipid Energy Model
- The Lipid Energy Model explains high LDL, high HDL, and low triglycerides on low-carb diets as increased VLDL trafficking and conversion to LDL.
- Adding carbohydrate to the liver reverses the driving force and should lower LDL rapidly.
Lean People Drive LDL Increases On Low Carb
- Meta-analysis of 41 RCTs found LDL increases on low-carb diets occur primarily in lean people.
- Overweight and obese participants showed no LDL rise or even decreases, making leanness a dominant predictor for LDL response.