Overview of IgG4 Related Disease

IgG4 related disease is a complex condition that has gained recognition in the medical community over the past decade. With a surge in literature and the establishment of classification criteria, the disease is now better understood. Dr. John Stone, a leading figure in the field, sheds light on the clinical presentation, diagnosis, and treatment options for IgG4 related disease. The disease can affect multiple organs, commonly presenting as head and neck involvement, orbital disease, or the presence of painless masses in various locations. Elevated serum IgG4 levels and classic radiological features can aid in the diagnosis. Treatment primarily focuses on B cell depletion therapy, which has shown efficacy in achieving long-term remission. Research is ongoing to better understand the pathophysiology, antigen triggers, and long-term outcomes of the disease.