Understanding IgG4-Related Disease: Early Discoveries and Common Presentations

This chapter explores the initial understanding of IgG4-Related Disease, highlighting the contributions of Japanese investigators and the puzzle of the disease being pieced together. It discusses the common presentations of IgG4-related disease, including head and neck involvement, orbital disease, and elevated serum IgG4 concentration. The chapter also delves into the symptoms experienced by patients, such as asymptomatic multi-organ involvement and weight loss due to exocrine pancreatic failure.