1) Optimal combination of secondary prevention drug treatment and stroke outcomes and 2) Topic of the month: Myelopathy due to systemic disease. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Andy Southerland interviews Dr. Bruce Ovbiagele about his paper on the optimal combination of secondary prevention drug treatment and stroke outcomes. Dr. Sarah Wesley is reading our e-Pearl of the week about persistent cryptococcal meningitis. In the next part of the podcast Dr. Ted Burns interviews Dr. Steven L. Lewis about the topic of myelopathy due to systemic disease: autoimmune disorders. The participants had nothing to disclose except Drs. Southerland, Ovbiagele, Wesley, Burns and Lewis.Dr. Southerland serves as Podcast Deputy Editor for Neurology®; serves as Clinical Research Advisor for Totier Technologies, Inc.Dr. Ovbiagele serves as an Assistant Editor of Stroke; serves as an Associate Editor of the Journal of Neurological Sciences; serves on the editorial board of the Journal of Stroke and Cerebrovascular Diseases and receives research support from the NIH.Dr. Wesley serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Ted Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with CSL Behring and Alexion Pharmaceuticals, Inc.Dr. Lewis serves as CME Section Co-Editor for Neurology® and as Editor in Chief for Continuum: Lifelong Learning in Neurology®; received royalties for book authorship and editorship from the publishers Wolters Kluwer and Wiley- Blackwell.