
JAMAevidence Users' Guides to the Medical Literature
Understanding the Results: More About Odds Ratios: Interview With Dr Gordon Guyatt
Mar 1, 2014
Dr. Gordon Guyatt, a leader in health research, joins Joan Stephenson, a PhD specializing in research methodologies. They delve into the nuances of odds ratios, comparing them with relative risks. The conversation highlights the critical importance of clearly communicating study results to patients. They also discuss the implications of accurately interpreting these ratios in clinical practice, especially in high-risk scenarios. Misconceptions about treatment effects are examined, emphasizing the need for careful evaluation in medical research.
10:30
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Quick takeaways
- Odds ratios, while useful, can lead to misinterpretations in high-risk clinical situations and require cautious interpretation by clinicians.
- Clinicians should prefer explaining absolute and relative risks to patients to enhance understanding over the less intuitive odds ratios.
Deep dives
Understanding Odds Ratios in Clinical Contexts
Odds ratios are a statistical measure often used to convey information about the likelihood of events occurring in medical studies. In a clinical setting, odds represent the probability of an event occurring compared to the probability of it not occurring, and this can be presented in various forms, such as 4 to 1 or 2 to 1. While odds are commonly understood in gambling contexts, they can be less intuitive for clinicians discussing patient outcomes. For example, a clinician might find it easier to explain an 80% chance of being cancer-free rather than saying there are odds of 4 to 1, indicating the need for clinicians to favor using absolute risks and relative risks in discussions with patients.
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