
JAMAevidence Users' Guides to the Medical Literature
JAMA editors and authors explain the methods underlying clinical research to help students, trainees, and health professionals use the published medical literature to make evidence-based decisions for patients. JAMAevidence is an evidence-based medicine (EBM) resource created and maintained by the JAMA Network to promote the use of EBM to improve patient care.
Latest episodes

Oct 3, 2024 • 15min
Teachers' Guides to the Users' Guides
Mark C. Wilson MD, MPH, University of Iowa, discusses Teachers’ Guides to the Users’ Guides with Gordon H. Guyatt, MD, MSc, McMaster University. Related Content: Evidence vs Consensus in Clinical Practice Guidelines How to Interpret and Use a Clinical Practice Guideline or Recommendation

Oct 5, 2023 • 16min
Assessing the Strength of Recommendations: The GRADE Approach With Dr Vandvik
Per Olav Vandvik, an expert in the GRADE approach, joins renowned researcher Gordon H. Guyatt for a compelling discussion. They dive into the importance of the GRADE framework for evaluating clinical recommendations. Hear about transforming evidence into practical guidelines while weighing benefits against harms. They also emphasize the role of systematic reviews and the process of assessing evidence certainty, shedding light on how observational studies and randomized trials can inform better patient care.

Sep 7, 2023 • 16min
Understanding and Applying the Results of a Systematic Review With Dr Murad
Host Gordon Guyatt, MD, MSc, discusses Understanding and Applying the Results of a Systematic Review with M. Hassan Murad, MD, MPH. Related Content: How to Read a Systematic Review and Meta-analysis and Apply the Results to Patient Care Acute Treatments for Episodic Migraine in Adults

Jul 6, 2023 • 21min
Fixed-Effects and Random-Effects Models With Dr Murad
Gordon H. Guyatt, MD, MSc, discusses Fixed-Effects and Random-Effects Models with M. Hassan Murad, MD. Related Content: Random-Effects Meta-analysis

Feb 2, 2023 • 17min
Adjusted Analyses in Studies Addressing Therapy and Harm With Dr Agoritsas
Gordon H. Guyatt, MD, MSc, discusses Adjusted Analyses in Studies Addressing Therapy and Harm with Thomas Agoritsas, MD, PhD. Related Content: Adjusted Analyses in Studies Addressing Therapy and Harm

Dec 1, 2022 • 14min
Spectrum Bias With Dr Reem A. Mustafa
Gordon Guyatt, MD, MSc, discusses Spectrum Bias with Reem A. Mustafa. MD, MPH, PhD.

Oct 6, 2022 • 17min
Discrimination and Calibration of Clinical Prediction Models With Dr Alba
Gordon Guyatt, MD, MSc, discusses Discrimination and Calibration of Clinical Prediction Models with Ana Carolina Alba, MD, PhD. Related Content: Discrimination and Calibration of Clinical Prediction Models With Dr Alba Read Transcript

Jul 7, 2022 • 32min
How to Interpret and Use a Clinical Practice Guideline or Recommendation With Dr Gordon Guyatt and Dr Brignardello-Petersen
Host Robert M. Golub, MD, discusses How to Interpret and Use a Clinical Practice Guideline or Recommendation with Gordon H. Guyatt, MD, MSc, and Romina Brignardello-Petersen, DDS, MSc, PhD.

Jun 2, 2022 • 15min
Measuring Agreement Beyond Chance With Dr Thomas McGinn
Gordon Guyatt, MD, discusses Measuring Agreement Beyond Chance with Thomas McGinn, MD, MPH. Related Content: Does This Patient Have Infectious Mononucleosis? The Rational Clinical Examination Systematic Review

Mar 3, 2022 • 16min
Correlation and Regression With Dr Jaeschke
Gordon H. Guyatt, MD, MSc, discusses
Remember Everything You Learn from Podcasts
Save insights instantly, chat with episodes, and build lasting knowledge - all powered by AI.