597: Expert insights on hormone replacement therapy for women

May 22, 2025

Delve into the transformative potential of hormone replacement therapy (HRT) for women and its profound impact on long-term health. Learn about the flawed study that shaped public perception and why it's time to rethink HRT. Experts discuss the different types of hormone therapies, the benefits they offer, and even touch on testosterone replacement for men. The conversation highlights the importance of proactive health management and empowers listeners to advocate for their personal health choices.

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INSIGHT

Flawed Study Misled On HRT

A major flawed study in the late 1990s scared many from using hormone replacement therapy (HRT).
It used synthetic hormones and new users over 65, leading to misinformation about HRT risks.

INSIGHT

HRT Boosts Women's Longevity

Hormone replacement therapy greatly reduces women’s risks of heart attacks, cognitive decline, and fractures.
It is one of the most impactful medical interventions for postmenopausal women's long-term health.

INSIGHT

Cautious Approach To TRT For Men

Testosterone replacement therapy (TRT) for men has promising benefits but needs cautious medical supervision.
Men should avoid non-medical sources and consult endocrinologists for TRT.

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“HRT is probably the best thing that you can do to improve long term health and longevity,” explains Amy Killen, M.D.

In this episode, we’re covering everything you need to know about hormone replacement therapy, including the incredible benefits of HRT and when you should consider starting HRT.

You’ll hear from:

Maddy Dychtwald, author, longevity expert, and co-founder of Age Wave, on the study that changed the way HRT was viewed and why it’s time to rethink that narrative
Marty Makay, M.D., the US Commissioner of Food and Drugs, a Johns Hopkins surgeon, public health expert, on why hormone replacement therapy may be one of the most powerful tools for women
Amy Killen, M.D., a longevity and regenerative medicine physician, on when to consider HRT and how it supports long-term health
Jessica Shepherd, M.D., OB/GYN and menopause expert, on the different types of hormone therapy and how to find a provider who supports your goals

We’ll cover:

- The flawed study that changed HRT perception (~1:05)

- The incredible benefits of HRT (~4:15)

- What about TRT for men? (~7:20)

- Hormone health is longevity (~8:45)

- When to consider HRT (~9:48)

- The different types of HRT (~11:10)

- You are the CEO of your health (~13:48)

Listen to the full episodes here:

- Why women live longer, but not better | Longevity expert Maddy Dychtwald

- The most common health myths, debunked | Marty Makary, M.D.

- Stem cells, HRT, & nitric oxide for women | Amy Killen, M.D.

- What women need to know about hormone replacement therapy (HRT) | Jessica Shepherd, M.D.

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