LONGEVITY with Nathalie Niddam #401: Personalization Is EVERYTHING: The New Science of Weight Health, GLP-1s, and Building Lasting Longevity With Ashley Koff
Jan 6, 2026
Join Ashley Koff, a registered dietitian and advocate for realistic nutrition, as she takes us on her transformative journey from marketing to health. She highlights the crucial role of personalized nutrition over one-size-fits-all diets, and the importance of digestion in weight health. Ashley explains the mechanics and risks of GLP-1 medications, emphasizing they aren't standalone solutions. Plus, learn about innovative strategies like the 'delicious to me' test for satiety and maintaining muscle during weight loss.
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Incretin Hormones Live In The Gut
- GLP-1 and other incretin hormones live in the gut lining and regulate appetite, satiety and blood sugar.
- Their natural activation lasts minutes, so prolonged pharmacologic activation has systemic consequences.
GLP-1s Are Biosimilar Hormone Replacement
- GLP-1 agonists are biosimilar hormone replacement, not magical one-off cures.
- Extending hormone activation from minutes to days changes physiology and requires careful use.
Pizza Pop Turned Into A Medical Win
- Ashley Koff took a resistant patient who ate a large pizza once daily and had him eat three slices every three hours to stabilize blood sugar and digestion.
- Within days he improved, lost weight, stopped diabetes meds, and made it to surgery, illustrating radical personalization wins.