Is Retatrutide the King of Fat Loss? Latest News & Study Breakdown

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Are you ready for the latest retatrutide news? In this video, I (Hunter Williams) dive deep into a brand new phase 2 study on retatrutide—Eli Lilly’s groundbreaking triple agonist peptide for fat loss and metabolic health. I break down the real-world body composition data, including fat loss, muscle loss, visceral fat reduction, and how retatrutide stacks up against other GLP-1 therapies like semaglutide and tirzepatide.

I’ll walk you through the DEXA scan results, discuss the clinical trial design, highlight key numbers (including fat loss index, total lean mass loss, and cardiovascular risk improvements), and share why more is not always better with retatrutide dosing. If you want to know what’s truly happening at the cutting edge of metabolic health—don’t miss this video!

Timestamps

0:00 – Introduction & why today’s retatrutide news matters
1:00 – Study background: Why body composition data is critical
2:08 – What is retatrutide? The triple agonist mechanism explained
3:07 – Retatrutide vs. other GLP-1s: The new study design
4:25 – Clinical trial details (participants, dosing, DEXA scan protocol)
6:24 – Key results: Total fat mass reduction at different doses
7:40 – Surprising findings: Is 8mg the “sweet spot” for fat loss?
8:35 – Total body weight loss vs. placebo and dulaglutide
9:21 – How much muscle do you lose on retatrutide? Lean mass data
10:13 – Visceral fat reduction: Why it matters for long-term health
11:12 – Impact on trunk/leg ratio & cardiovascular risk markers
12:08 – Fat loss index: Proportion of fat vs. muscle lost
13:19 – Retatrutide vs. semaglutide and tirzepatide: Head-to-head data
14:50 – Safety profile & common side effects
15:31 – The role of glucagon receptor agonism & future of peptide therapies
16:38 – Main takeaways: More is not always better with retatrutide
17:41 – Big picture: What’s next for retatrutide and obesity treatment?
18:44 – Final thoughts, feedback, and gratitude

👇 Drop your thoughts and questions below. For more deep dives, subscribe and check out the links in the description—including the peptide cheat sheet and the full study!