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The HDR1A gene influences the production of 5HT1A serotonin receptors that play a crucial role in serotonin signaling within the brain. Postsynaptic 5HT1A receptors, located on the neuron receiving the serotonin signal, help enhance mood and reduce anxiety. On the other hand, presynaptic 5HT1A receptors, situated on the serotonin-releasing neuron, regulate serotonin release to maintain balanced levels. Variants like SNP RS6295 can impact the expression of these receptors, affecting functions related to mood regulation, stress response, and mental well-being.