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Oncotarget

Anticancer Potential of CLK Kinase Inhibitors 1C8 and GPS167 via EMT and Antiviral Immune Response

May 20, 2024
Researchers discuss the anticancer potential of CLK kinase inhibitors 1C8 and GPS167, revealing their impact on cancer cell proliferation, epithelial-mesenchymal transition, and antiviral immune response. Molecular mechanisms underlying the inhibitors' effects on processes critical for metastasis are explored.
03:19

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Quick takeaways

  • CLK kinase inhibitors 1C8 and GPS167 affect cancer cell proliferation by targeting mitotic spindle assembly components.
  • Compounds 1C8 and GPS167 have broader effects on tumor progression, EMT, and the antiviral immune response.

Deep dives

Impact of CLK Kinases Inhibitors on Cancer Cell Proliferation

The research paper published in Anco Targets Vol. 15 highlighted the anticancer potential of compounds 1C8 and GPS167, which inhibit the CLK kinases and affect the proliferation of various cancer cell lines. Through chemogenomic screening, it was found that these compounds influence components associated with mitotic spindle assembly, thereby altering sensitivity to GPS167. Transcriptome analyses revealed that the expression and RNA splicing of transcripts encoding mitotic spindle assembly components were affected by 1C8 and GPS167. This study confirmed the functional relevance of the microtubule connection and demonstrated that drugs impacting mitotic spindle assembly increased sensitivity to GPS167, shedding light on the molecular mechanisms underlying cancer cell proliferation.

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