The Peter Attia Drive

#67 - AMA #8: DNA tests, longevity genes, metformin, fasting markers, salt, inflammation, and more

Aug 19, 2019
In this engaging AMA session, intriguing questions about DNA tests and their usefulness for health insights are tackled. The discussion shifts to longevity genes and whether they appear on genetic tests like 23andMe. Metformin is examined for its potential longevity benefits, followed by a dive into the role of salt in health risks. Inflammation markers are explored, with insights into what can be done to reduce them. Additionally, Peter shares his preferred lipid tests and highlights fascinating findings from his quarterly fasts.
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INSIGHT

Cancer and Genetics

  • Genetic tests like 23andMe offer limited value for predicting or preventing most cancers.
  • Most cancers arise from somatic mutations acquired during life, not inherited germline mutations.
ADVICE

Cardiovascular Disease and Genetics

  • Measure lipoprotein(a) directly for cardiovascular disease risk assessment, rather than relying on genetic tests.
  • Phenotypic measurement is more informative and actionable than genetic predisposition.
INSIGHT

Diabetes and Genetics

  • Peter Attia finds phenotypic data more useful than genetic predisposition for diabetes.
  • Tracking metrics like hyperinsulinemia and CGM data offers better insights and actionability.
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