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Oncotarget

NSD2 Gene Drives Cancer Cell Identity in Multiple Myeloma

Mar 25, 2025
Explore the intriguing role of the NSD2 gene in maintaining the identity of multiple myeloma cells as plasma cells. Researchers delve into how NSD2 influences gene activity, offering new perspectives on treatment for high-risk t(4;14) myeloma. They compare myeloma cells with varying NSD2 activity and uncover significant changes in DNA folding and gene expression. This groundbreaking study could lead to innovative strategies for tackling this challenging form of blood cancer.
04:39

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Quick takeaways

  • NSD2 is essential for sustaining the plasma cell identity of multiple myeloma cells by influencing gene activity and DNA folding.
  • Targeting NSD2 may enhance immunotherapy effectiveness and reshape treatment strategies for patients with high-risk t(4;14) multiple myeloma.

Deep dives

Role of NSD2 in Multiple Myeloma Cells

NSD2 is crucial for maintaining the identity of multiple myeloma cells as plasma cells, which are essential for immune function. The research revealed that high activity of the NSD2 gene influences DNA folding and the activation or silencing of various genes that are vital for plasma cell characteristics. When NSD2 activity was turned off, significant markers such as CD38 significantly decreased, while genes usually inactive in plasma cells became activated. This suggests that NSD2 does not directly control the primary genes for plasma cell creation but rather affects a multitude of other genes that help sustain the cancer cell's identity.

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