320: Jim Wilson's next venture, a surprise startup shutdown, & Lilly's Zepbound strategy
Aug 29, 2024
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In this engaging discussion, gene therapy pioneer Jim Wilson, known for his groundbreaking work at the University of Pennsylvania, shares insights on his recent departure and future plans. Joining him is Jonathan Wosen, a biotech reporter, who sheds light on the surprising closure of a gene editing company and the challenges facing the industry. They explore Eli Lilly's new pricing strategy for its obesity drug, Zepbound, and the shift toward direct-to-consumer sales. The conversation captures the dynamic, often unpredictable nature of biotech today.
Jim Wilson's exit from the University of Pennsylvania reflects the challenges and funding declines impacting the gene therapy field.
The collapse of gene editing startup Tome illustrates the volatile nature of biotech investments and shifting investor sentiment in the sector.
Deep dives
Jim Wilson Leaves UPenn Amid Industry Funding Challenges
Jim Wilson, a pioneer in gene therapy, is departing from the University of Pennsylvania due to a significant decrease in industry funding for academic research and various challenges within the gene therapy sector. After years of generating substantial revenue through partnerships, Wilson noted a drastic shift where obtaining funding became increasingly difficult. His departure marks the end of a successful yet turbulent era, characterized by lucrative licensing deals and the establishment of numerous biotech companies. He aims to transition his work into two newly formed companies, reflecting a strategic shift to tackle issues in the worsening funding environment for research.
The Demise of Gene Editing Startup Tome
The sudden downfall of gene editing startup Tome has stirred concern within the biotechnology community, particularly due to its rapid rise and fall within less than a year after securing over $213 million in funding. Following significant spending and a quickly initiated acquisition of another startup, Tome found itself unable to sustain operations and announced sweeping layoffs. This case highlights potential overextensions and the volatile nature of early-stage biotech investment, especially as investor sentiment has shifted away from preclinical companies. The situation underscores a broader trend of startups facing challenges in raising subsequent funding rounds amid tightened capital conditions.
Eli Lilly's New Drug Pricing Strategy Raises Concerns
Eli Lilly's recent announcement regarding a discounted version of its obesity drug, Zepbound, has drawn scrutiny for its limited accessibility and accompanying price hikes for existing products. While the company claims to increase access by offering vials at reduced prices, these are only for cash-paying patients and represent low-dose starter options. Moreover, Lilly's simultaneous increase in the coupon price for injectable pens raises questions about the transparency and intentions behind their discount strategy. Skeptics suggest that such measures may serve more to enhance market share and control rather than genuinely improve accessibility for consumers.
Shifting Investor Sentiment in the Biotech Sector
The podcast examines the evolving investor sentiment in the biotech sector, particularly emphasizing how changing economic conditions and interest rates affect funding availability. As companies navigate a tough landscape, the environment is shifting away from supporting early-stage ventures and leaning towards clinical companies. Such transitions have led to heightened scrutiny on investments, with discussions around the future viability of gene therapies becoming more prevalent. This paradigm shift highlights the challenges facing startups and the increasing competition for funding in an industry where the financial climate is becoming more cautious.
STAT biotech reporter Jonathan Wosen joins us to discuss gene therapy pioneer Jim Wilson's exit from his decades-long tenure at the University of Pennsylvania. We also discuss the latest news in the life sciences, including the surprising collapse of a gene editing company, Eli Lilly's pitch to consumers, and more.
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