“The HemOnc Pulse” Live 2024 in Chicago: CAR-T Unanswered Questions
May 4, 2024
auto_awesome
Dive into the live meeting in Chicago discussing CAR-T therapy with experts Caron Jacobson and Michael Bishop. Topics include challenges in using CAR-T for solid tumors, complexities in myeloma treatment, nuances in oncology, long-term complications, secondary malignancies, Richter's Transformation, and expanding treatment options in T-cell therapy.
CAR-T therapy shows promise in hematologic malignancies but faces challenges in solid tumors.
Exploring alternative platforms like TCR-modified T cells or NK cells may address CAR-T therapy limitations.
Deep dives
Unanswered Questions in CAR-T Cellular Therapy
The podcast episode discusses the top three unanswered questions in CAR-T cellular therapy. It highlights concerns about the efficacy of CAR-T cells in solid tumors compared to hematologic malignancies. The potential of TCR-modified T cells or NK cells as an alternative platform is explored to address challenges faced by CAR-T cells. The discussion emphasizes the need for further research and comparison between different cellular therapeutic approaches.
Challenges in Myeloma and Bridging Strategies for CAR-T Therapy
The episode delves into the challenges in myeloma treatment and the unanswered questions surrounding CAR-T therapy. It explores the complexities of neurological toxicities in myeloma patients undergoing CAR-T treatment and the need for better understanding and management. Additionally, the discussion touches on the effectiveness of CAR-T therapy in earlier treatment lines and the importance of evaluating bridging strategies for patients, including the role of autologous transplants.
Long-Term Complications and Considerations in CAR-T Therapy
The podcast addresses long-term complications post-CAR-T therapy and the ongoing considerations for patients. It highlights the importance of monitoring and addressing potential adverse effects, such as hypogammaglobulinemia and secondary malignancies. The discussion emphasizes the need for comprehensive registries to track long-term outcomes and strategies to minimize risks while optimizing access and efficacy of CAR-T treatments.
Future Prospects: Bi-specifics and Selecting Therapy Approaches
The episode explores future prospects in CAR-T therapy, focusing on the role of bi-specifics and selecting optimal therapy approaches. It discusses the potential of bi-specific antibodies in bridging gaps in efficacy and reducing long-term toxicities associated with CAR-T therapy. The conversation touches on the challenges of sequencing therapies and the evolving landscape of treatment options for aggressive lymphomas, emphasizing the need for strategic treatment selection and cost considerations.
“The HemOnc Pulse” goes on the road to Chicago May 3-4 with host Chadi Nabhan, MD, MBA, FACP, for the first live meeting.
This podcast episode features a panel discussion on unanswered questions in chimeric antigen receptor (CAR) T-cell therapy with Caron Jacobson, MD, MMSc, Medical Director of the Immune Effector Cell Therapy Program at Dana-Farber Cancer Institute; Michael Bishop, MD, FACP, FASCO, Director of the Hematopoietic Stem Cell Transplantation Program at the University of Chicago; Joseph Mikhael, MD, MEd, FRCPC, FACP, a Professor in the Applied Cancer Research and Drug Discovery Division at the Translational Research Institute, an affiliate of the City of Hope Cancer Center; and Alan Skarbnik, MD, Director of the Lymphoma and Chronic Lymphocytic Leukemia Program and Director of Experimental Therapeutics, Malignant Hematology at Novant Health.
Get the Snipd podcast app
Unlock the knowledge in podcasts with the podcast player of the future.
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode
Save any moment
Hear something you like? Tap your headphones to save it with AI-generated key takeaways
Share & Export
Send highlights to Twitter, WhatsApp or export them to Notion, Readwise & more
AI-powered podcast player
Listen to all your favourite podcasts with AI-powered features
Discover highlights
Listen to the best highlights from the podcasts you love and dive into the full episode