The Cabral Concept 3632: Why Methylation Supplements Usually Backfire (TT)
Jan 15, 2026
Could your methylation supplements be doing more harm than good? Discover how simply adding methyl donors like B9 and B12 may not fix the underlying issues. Learn about the importance of foundational nutrients like riboflavin, B6, and magnesium for overall health. Understand why a full B-complex is essential instead of cherry-picking vitamins. Plus, find out how overloading on methyl donors can lead to increased anxiety and insomnia. Tune in for practical strategies to support your methylation effectively!
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Methyl Donors Aren't The Whole Solution
- Methylfolate (B9) and methylcobalamin (B12) are methyl donors but do not fix methylation pathways by themselves.
- Providing cargo without the transport machinery can leave methylation dysfunctional and cause symptoms to worsen.
Riboflavin Is The Methylation Engine
- Riboflavin (B2) converts to FAD, an electron carrier that activates and shuttles B9 and B12 where needed.
- Without B2 the methyl donors can't be effectively transported or activated in tissues.
Use P5P And Magnesium For Nervous System Balance
- Include P5P (activated B6) and magnesium to support neurotransmitter balance and nervous system recovery.
- Use B6 especially if you experience anxiety, overstimulation, or 'tired and wired' symptoms.
