Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast Episode 193: Keywords Part 15: Pharmacology of Inhaled Anesthetics
Feb 1, 2021
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Blood Gas Partition Coefficient Insight
- Blood gas partition coefficient describes gas concentration ratio between blood and alveoli at equilibrium.
- A higher coefficient means more soluble agent, leading to slower induction and recovery.
Adjust MAC for Physiological States
- Remember physiological and pathological states affect MAC value of volatile anesthetics.
- Adjust anesthesia for factors like hyperthermia, hypothermia, anemia, and acute ethanol ingestion accordingly.
Volatiles Effects on Circulation & Respiration
- Volatile anesthetics generally lower mean arterial pressure by vasodilation and may cause reflex tachycardia.
- They produce rapid shallow breathing with decreased tidal volume and increased respiratory rate.