NEJM This Week NEJM This Week — August 7, 2025
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Aug 6, 2025 Delve into innovative treatments for chronic kidney disease and diabetes, along with groundbreaking trials for advanced breast cancer. Explore the complexities of hormone treatments in older patients while addressing autoimmunity and racial health disparities. The discussion also sheds light on the effects of profit-driven motives in healthcare. Uncover challenges in medical communication and the evolving role of physicians, all wrapped in personal reflections on how culture shapes medical aspirations.
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Combination Therapy Advances CKD Care
- Combining finarenone and empagliflozin reduces albuminuria more than either alone in CKD with type 2 diabetes.
- Early combination therapy shows promise but requires monitoring and long-term outcome data.
Oral Ciprofloxacin Effective for Plague
- Oral ciprofloxacin alone is as effective as aminoglycoside plus ciprofloxacin for treating bubonic plague.
- This supports FDA's use of animal efficacy rule for fluoroquinolone approval and simplifies treatment.
Targeted ER Degraders in Breast Cancer
- Vepdegastrant shows improved progression-free survival only in ESR1-mutated advanced breast cancer subgroup, not overall.
- Switching to camizestrant with CDK4-6 inhibitor at ESR1 mutation detection delays progression more than continuing aromatase inhibitor.