In this episode, trauma expert Dr. Zaf Qasim engages in a candid and insightful discussion on trauma management with a focus on resuscitation strategies. The conversation covers various aspects, from challenging dogmas in trauma care to addressing specific scenarios like traumatic arrest. Zaf emphasizes the importance of tailoring interventions based on the unique physiology of traumatic arrest, distinguishing it from medical arrest. He delves into the sequence of procedures, advocating for a methodical approach that prioritizes addressing reversible issues. The debate extends to the use of vasopressors in trauma-induced hypotension, with a spotlight on vasopressin as a potential agent. The discussion also touches on crystalloid administration in the absence of immediate blood availability and the role of calcium in trauma resuscitation. Zaf provides insights into the evolving consensus on tranexamic acid (TXA) use, including dosing considerations, and sheds light on the integration of TXA into trauma protocols. The episode concludes with audience questions, exploring topics such as RSI in trauma, including considerations for induction doses, and the role of pericardiocentesis in trauma patients with effusion or tamponade. Overall, the episode offers a valuable blend of evidence-based practices and practical considerations for trauma resuscitation.