ResusX:Podcast

When a patient is crashing and every second counts, airway decisions can mean life or death. For decades, clinicians have fiercely debated: should you reach for etomidate, the hemodynamic workhorse, or ketamine, the pressure-friendly multitasker? In this episode, we dive deep into a new systematic review and meta-analysis that just might end the controversy once and for all. The surprising truth? Survival doesn’t change no matter which drug you choose. We’ll unpack: Why this finding is a game-changer for emergency physicians, intensivists, and resuscitationists. What the evidence really says about mortality, intubation success, and cardiac arrest risk. The nuances of post-induction hypotension and why it might not be the dealbreaker it once seemed. How this study frees you to make airway decisions based on patient context and clinical judgment—not dogma. Whether you’re on the front lines of the ED, running codes in the ICU, or training the next generation of airway masters, this episode will leave you with clarity, confidence, and a renewed perspective on one of emergency medicine’s longest-running debates.

When major abdominal surgery pushes patients to the brink, timing is everything, especially with norepinephrine. Could giving it earlier to high-risk patients prevent dangerous drops in blood pressure and reduce complications? A new randomized controlled trial, published in Anesthesiology (2025), put this to the test, comparing early, low-dose norepinephrine infusion against standard care in high-risk surgical patients. The results may surprise you: early norepinephrine not only stabilized blood pressure faster but also significantly reduced postoperative complications without increasing adverse events. In this episode, we break down what “early” really means, why the trial’s pragmatic design matters, and how this could reshape perioperative hemodynamic management in major surgery. Key takeaways: • Early norepinephrine led to more stable intraoperative blood pressure • Reduced risk of postoperative complications in high-risk patients • No significant increase in adverse events compared to standard care This isn’t just about drugs, it’s about redefining timing in critical surgical care. Want to dig deeper? Check out the full study: Trocheris-Fumery O, Flet T, Scetbon C, et al. Early Use of Norepinephrine in High-Risk Patients Undergoing Major Abdominal Surgery: A Randomized Controlled Trial. Anesthesiology. 2025. doi:10.1097/ALN.0000000000005704

When it comes to getting patients off mechanical ventilation, clinical judgment isn’t always enough. What if you could use a real-time, bedside tool to boost your confidence—and your success rate? In this episode, we dive into the power of diaphragmatic ultrasound in predicting successful weaning from mechanical ventilation. Based on the latest meta-analysis, we break down how measuring diaphragm function—like excursion and thickening fraction—can provide moderate-to-high diagnostic accuracy in identifying who’s ready to breathe on their own. Find out: Why traditional predictors aren’t cutting it What makes diaphragmatic ultrasound a game-changer And whether this tool should become your new go-to in the ICU Based on the article of Tashiro, N., Nishiwaki, H., Ikeda, T. et al. titled "Clinical utility of diaphragmatic ultrasound for mechanical ventilator liberation in adults: a systematic review and meta-analysis" from j Intensive Care.

Can IV vitamin C really save lives in the PICU? It’s been a hot topic in critical care circles for years—but the VITACIPS trial just delivered a powerful dose of clarity. In this episode, we dive into the results of this rigorous study and what they mean for treating children in septic shock. Spoiler: it’s not the magic bullet many hoped for. We break down key findings, clinical implications, and why this trial is a turning point in how we think about adjunct therapies in pediatrics. Whether you're treating pediatric patients or just curious about how cutting-edge research shapes real-world care, this one’s worth the listen. Based on the article: “Vitamin C Versus Placebo in Pediatric Septic Shock (VITACIPS) – A Randomised Controlled Trial” by Jhuma Sankar et al., Journal of Intensive Care Medicine.

What happens when a patient in the ICU suddenly can't breathe—and the usual airway tools just won’t cut it? In this episode, we break down the high-stakes world of difficult airway management where seconds matter and lives hang in the balance. From using checklists like LEMON to deploying advanced gear like video laryngoscopes and rescue devices, this isn’t just medicine—it’s a strategic, lifesaving playbook in action. We explore the latest evidence, essential algorithms, and game-changing tools that are helping clinicians stay calm, stay sharp, and save lives when the pressure is highest. Whether you're on the frontlines or just curious how modern medicine handles its toughest challenges, this is an episode you don’t want to miss. Based on the article: “Difficult Airway Management in the Intensive Care Unit: A Narrative Review of Algorithms and Strategies” by Talha Liaqat et al., Journal of Clinical Medicine.

When seconds count and precision matters—like during surgery—getting accurate, continuous blood pressure readings is critical. That’s where radial artery cannulation comes in. But while traditional methods rely on “feeling the pulse,” they’re not always reliable, especially in tough cases. Enter a game-changing technique: ultrasound-guided Dynamic Needle Tip Positioning (DNTP). In this episode, we dive into a powerful new study that compares old-school palpation to DNTP and the results are stunning: an 88.5% first-pass success rate, fewer attempts, less time, and reduced equipment use with the ultrasound approach. We explore why this matters for patient safety, comfort, and clinical efficiency—and how this could redefine arterial cannulation in the OR. Could this be the new gold standard for arterial access? Tune in and find out. Read the full study: "Palpation versus Ultrasound-Guided Dynamic Needle Tip Positioning Technique for Radial Artery Cannulation" by Sujan Dhakal et al. in Annals of Cardiac Anaesthesia.

When someone is critically ill, whether battling sepsis, ARDS, or severe pneumonia, corticosteroids have long been a debated topic. A massive new meta-analysis pooling data from over 10,000 ICU patients finally brings clarity. The headline: early, low-dose, prolonged steroid therapy cuts short-term mortality by roughly 15%, slashes ICU stays by 2 days, reduces time on ventilators by over 4 days, and boosts ventilator-free days—all without increasing infection or bleeding risks. Sure, there’s a slight uptick in hyperglycemia, but that’s a small price for improved survival and recovery  What does this mean for frontline clinicians? Think “early, gentle, and sustained.” Start steroids within the first 72 hours, keep them on for at least a week, and tailor doses to lower than 400 mg of hydrocortisone per day. Most surprisingly, even septic shock patients benefit most when hydrocortisone is paired with fludrocortisone Want to see the full picture? Check out the study: “Efficacy and safety of corticosteroids in critically ill patients” by Lei Cao et al. in BMC Anesthesiology (July 2025).

When seconds count in the ICU, the IV fluid you choose could literally make or break a patient’s recovery. In this episode, we’re unpacking one of the biggest debates in critical care: balanced crystalloids vs. normal saline. A massive new meta-analysis of over 35,000 patients drops a game-changing truth—your fluid choice must depend on whether the patient has a traumatic brain injury (TBI). Balanced solutions may lower mortality in most critically ill patients, but for those with TBI, they could actually do harm. Tune in to hear how this data is flipping standard practice on its head and pushing the ICU world toward smarter, personalized resuscitation. Want to dive deeper? Check out the full study “Effect of Treatment With Balanced Crystalloids Versus Normal Saline on the Mortality of Critically Ill Patients With and Without Traumatic Brain Injury” by José C. Diz et al. in Critical Care and Resuscitation.

In today’s episode, we’re diving into a game-changing question: Can swapping fentanyl for remifentanil help ventilated ICU patients breathe on their own sooner, and with fewer complications like delirium? This fresh meta-analysis pulls data from multiple studies and suggests remifentanil could reduce ventilation time by up to 21 hours in some cases and may lower the risk of ICU-related delirium. While the evidence is still growing and more rigorous trials are needed, the findings raise big questions about how we manage pain and recovery in critical care. Tune in for key takeaways, clinical implications, and what this could mean for the future of ICU sedation. Want to go deeper? Read the full study: "Comparative efficacy of remifentanil and fentanyl in mechanically ventilated ICU patients: a systematic review and meta-analysis on ventilation duration and delirium incidence" by Hiromu Okano et al. in Journal of Anesthesia, Analgesia and Critical Care.

When it comes to oxygen therapy for critically ill, ventilated patients, more isn’t always better—but is less the answer? The UK-ROX trial set out to find out, tracking over 16,000 ICU patients across 97 hospitals to test if targeting lower oxygen saturation (SpO₂ ~90%) could improve survival rates. Spoiler alert: it didn’t. In this episode, we unpack why conservative oxygen therapy didn’t significantly impact 90-day mortality—and what that means for frontline ICU care today. With no meaningful differences in mortality, ICU stays, or days free from organ support, the results suggest that “usual care” oxygen strategies may already be doing the job. Key takeaways: • Conservative O₂ therapy didn’t improve survival • 90-day mortality nearly identical across groups • Usual care remains a safe and effective standard Breathe easy—this episode cuts through the noise and gives you the real clinical takeaways. Want to dig deeper? Check out the full study: "Conservative Oxygen Therapy in Mechanically Ventilated Critically Ill Adult Patients" by Daniel S. Martin et al., published in JAMA.