The podcast explores the business story behind blockbuster drugs like Ozempic for weight loss. It focuses on the Novo Nordisk scientist who invented the compound paving the way for Ozempic. It discusses the development, impact, and challenges faced in the pharmaceutical market and the affordability issues related to weight loss medications.
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Quick takeaways
Development of GLP-1 drugs for weight loss originated from Novo Nordisk's innovation.
Affordability of GLP-1 medications poses a significant barrier for individuals seeking weight loss treatment.
Deep dives
Development of GLP-1 Drugs for Weight Loss
The podcast episode delves into the origin story of GLP-1 drugs, specifically focusing on Novo Nordisk's development of Ozempic. Initially designed to treat diabetes, these drugs were found to aid in weight loss. The journey of creating a long-lasting GLP-1 compound that led to the development of liraglutide, later known as Victoza, is highlighted. Despite initial setbacks, the perseverance and innovation of the team led to the approval of these drugs, paving the way for significant weight loss outcomes.
Rise of Pharmaceutical Giants
The episode discusses how pharmaceutical companies like Novo Nordisk and Eli Lilly ventured into the realm of weight loss medications by leveraging GLP-1 compounds. Novo's launch of Ozempic in 2018 marked a turning point, leading to a surge in popularity driven by its potential for weight loss. The competitive landscape intensified as Eli Lilly introduced Mount Jaro and Zepbound, offering effective alternatives to combat obesity.
Issues of Drug Affordability and Availability
An important facet of the podcast episode addresses the challenges of affordability and availability surrounding GLP-1 medications for weight loss. The high costs, approximately $1,000 a month, present a significant barrier for many individuals, especially when insurance coverage is limited. The episode sheds light on the dilemma faced by individuals like Brad, who had to discontinue treatment due to financial constraints, leading to concerns about relapse in weight gain.
Implications and Societal Impact
The podcast episode underscores the far-reaching implications of the rise of GLP-1 drugs for weight loss, prompting discussions on their societal impact. With rising demand for these medications and their potential to revolutionize obesity treatment, questions arise about the long-term effects on healthcare systems and individuals. The episode highlights the transformative effect of these drugs on individuals' lives, showcasing their significance in reshaping the landscape of weight loss treatments.
Today we’re presenting Trillion Dollar Shot, a new series that explores the business story behind the rise of Ozempic and other blockbuster drugs being used for weight loss. The first episode focuses on the Novo Nordisk scientist who invented the compound that paved the way for Ozempic. You can find every episode on The Journal’s show feed.
Trillion Dollar Shot is part of The Journal, which is a co-production of Spotify and the Wall Street Journal. This episode was hosted by Jessica Mendoza, with Bradley Olson. It was produced by Matt Kwong, with help from Jeevika Verma. Additional production from Adrienne Murray Nielsen. The series is edited by Katherine Brewer. Sound design and mixing by Peter Leonard. Mixing for Science Vs by Bobby Lord. Music in this episode by Peter Leonard and Bobby Lord. Theme music by So Wylie, remixed for this series by Peter Leonard. Special thanks to Maria Byrne, Stefanie Ilgenfritz, Kate Linebaugh, Peter Loftus, Sara O’Brien, Enrique Perez De La Rosa, Sarah Platt, Sune Rasumssen, Jonathan Sanders, Nathan Singhapok, Leying Tang, Rolfe Winkler, Liz Essley Whyte, and Tatiana Zamis.