Huberman Lab

Health Effects & Risks of Kratom, Opioids & Other Natural Occurring Medicines | Dr. Chris McCurdy

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Jul 21, 2025
Guest
Chris McCurdy
Dr. Chris McCurdy, a medicinal chemistry professor at the University of Florida, explores the complex effects of kratom and its potential as an opioid substitute. He discusses its traditional uses for energy and mood enhancement while addressing critical safety concerns, addiction risks, and the variances in kratom products. McCurdy highlights the fine line between natural medicinal benefits and risks, explaining how the commercialization of kratom may mislead users. The conversation also touches on the historical significance of plant-derived compounds in modern health.
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Traditional Kratom Effects

  • Kratom traditionally provides stamina and energy for rural laborers in Southeast Asia.
  • It acts as a stimulant at low doses and as a sedative or euphoric at higher doses, showing paradoxical effects.
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Kratom Products Vary Greatly

  • Traditional kratom leaf use involves dried leaf material slowly extracted by the body.
  • Concentrated extracts or isolates deliver compounds faster and in higher doses, altering effects and risks.
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Understand Kratom Product Types

  • Avoid confusing kratom products by comparing them to traditional leaf versus concentrated extracts.
  • Always research product type to understand dosage, potency, and risks before use.
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