Two Onc Docs Stem Cell Transplant (SCT) Part 2 x Dr. Jeff Auletta 2025 UPDATE
May 5, 2025
Jeff Auletta, a pioneer in stem cell transplantation and infectious diseases, shares insights from his role at the National Marrow Donor Program. He explores the intricacies of conditioning regimens, including myeloblative and non-myeloablative methods. The conversation delves into the complexities of graft-versus-host disease, highlighting treatment strategies and challenges. Auletta also emphasizes the importance of managing transfusion complications and shares his emotional connections with pediatric patients, underscoring the vital role of stem cell research.
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Types and Toxicities of Conditioning Regimens
- Conditioning regimens vary by intensity: myeloablative, reduced intensity, and non-myeloablative.
- All have acute and chronic toxicities including cytopenias, organ damage, infections, and long-term organ dysfunction.
Key Busulfan Risks and Infection Vigilance
- Be aware that busulfan can cause seizures and veno-occlusive disease during transplant.
- Monitor closely for infections like bacterial, fungal, and viral post-conditioning.
Engraftment Timing Depends on Source
- Autologous stem cell transplantation engrafts faster (10-12 days) than allogeneic.
- Peripheral blood stem cells engraft faster than bone marrow or umbilical cord blood.