The Made to Thrive Show The Cholesterol Masterclass 101: How Oreos Reduce Cholesterol, ApoB, and What Causes Heart Disease. Dave Feldman
Jun 4, 2025
In this engaging discussion, Dave Feldman, a senior software engineer and entrepreneur passionate about cholesterol research, questions conventional wisdom about cholesterol's role in heart health. He introduces the revolutionary idea that cholesterol may function as an energy adaptogen. The conversation playfully explores how eating Oreos can lower LDL as effectively as statins. Feldman also highlights the importance of understanding ApoB, the lean mass hyper responder phenomenon, and innovative health assessments for better cardiovascular health.
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Plaque Predicts Plaque, Not ApoB
- The presence of plaque predicts more plaque progression, while ApoB or LDL levels do not correlate with it.
- This challenges the traditional belief that LDL cholesterol directly predicts cardiovascular disease progression.
Lean Mass Hyper-Responder Lipid Pattern
- In lean, metabolically healthy people on low-carb diets, LDL can rise as a normal energy trafficking response.
- This triad of high LDL, high HDL, and low triglycerides indicates an active fat metabolism, not necessarily risk.
Check Imaging Before Treating LDL
- If you have high LDL as a lean mass hyper-responder, get imaging to check your CAC or CT angiogram.
- If plaque is low or zero, managing lipid levels may not be urgent for cardiovascular risk.