In this podcast episode, emergency medicine physician Chris Reilly discusses the "6 P's of Pre-Oxygenation" crucial for successful intubation, especially in hypoxemic patients. He begins by explaining the physiology of oxygen delivery and the importance of achieving high oxygen saturation before intubation to avoid complications like post-intubation cardiac arrest. Reilly outlines the steps for effective pre-oxygenation: Positioning the patient properly, using Prongs and a Non-Rebreather mask, Pondering the patient's oxygen saturation (SAT), ensuring an adequate Pre-Ox period, Pushing medications for rapid sequence intubation, and utilizing Passive Apneic Oxygenation. He emphasizes creating an oxygen reservoir by denitrogenating the lungs and maintaining optimal oxygen levels throughout the procedure to extend safe apnea time and minimize risks.