Ep. 76: “Innate-Like T Lymphocytes” Featuring Dr. Mitchell Kronenberg
Apr 9, 2024
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Dr. Mitchell Kronenberg discusses his research on innate-like T cells and mucosal immunology, along with recent advancements in immunology science. Topics include immune system regeneration, antibody-drug conjugates for cancer, and the impact of Gasdermin in Pyroptosis. The episode also touches on AI in immunology research, targeting TRBC1 in T cell cancers, and exploring non-canonical T cells.
Innate-like T cells exhibit diverse functions including tissue regeneration despite being pro-inflammatory often associated with COVID-19 responses.
Dr. Mitchell Kronenberg's interest in acting and comedy showcases a passion for creativity beyond immunology research and leadership roles.
Successful research partnerships at La Jolla Institute emphasize mission-driven focus, collaboration, and adaptability without bureaucratic constraints.
Deep dives
The Versatility and Special Focus of the La Jolla Institute
The La Jolla Institute for Immunology is a unique research institute with a strong mission focus on research without the burden of excessive bureaucracy. Located in the Torrey Pines Mesa in San Diego, it stands among other prestigious research institutions like the Salk Institute and the Scripps Research Institute. With a pure mission to conduct great science, the Institute benefits from partnerships with a Japanese company, Chio Kairan, and collaborations with the University of California, San Diego, which provide crucial support and resources while maintaining a sense of independence in research endeavors.
Dr. Mitchell Cronenberg's Journey and Alternate Career Interest
Dr. Mitchell Cronenberg, a renowned immunologist, shared his passion for acting and comic performance as an alternate career interest. Although pursuing a career in acting did not materialize due to a focus on intellectual stimulation and creativity in science, his involvement in comedic plays and amateur performances highlighted his creativity and willingness to engage in different forms of expression beyond research and academia.
Unconventional T Cells and Their Multifaceted Roles
Unconventional T cells, including mucosal-associated invariant T cells (MAIT) and natural killer T (NKT) cells, play multifaceted roles in immunology, exhibiting responses similar to innate immunity patterns. Dr. Cronenberg emphasized their ability to promote tissue regeneration, despite commonly being associated with pro-inflammatory functions. Their distinct activation profiles during infections like COVID-19 underscore their significant yet complex contribution to immune responses.
Dr. Cronenberg's Enthusiasm for Creative Pursuits
Dr. Cronenberg's interest in engaging in creative pursuits beyond science, such as acting and comic performances, reflects his passion for creativity and humor. While his career path led him to immunology research and academic leadership, his appreciation for creativity and expression through different mediums, such as plays and performances, continues to inspire his multifaceted interests.
Navigating Research Partnerships and Collaborations at La Jolla
La Jolla Institute's effective navigation of partnerships with industry and academic institutions is attributed to a mission-driven focus and a collaborative ethos. Dr. Cronenberg's insight into fostering strong relationships with partners like Chio Kiron and the University of California, San Diego, showcases the importance of listening, adaptability, and mutual support in building successful research collaborations without excessive bureaucracy.
Closing Remarks and Special Insights from Dr. Cronenberg
Dr. Mitchell Cronenberg's interview highlighted his unique journey in immunology research, engaging in creative pursuits, and navigating partnerships at the La Jolla Institute. His enthusiasm for acting and comedy, alongside his impactful contributions to science, illustrated the blend of creativity, intellectual stimulation, and purposeful collaboration that define his professional and personal pursuits.
Dr. Mitchell Kronenberg is a Professor and President Emeritus at La Jolla Institute for Immunology. His lab studies how innate-like T cells adapt to different tissue environments. He talks about his work on MAIT cells and mucosal immunology, as well as his time leading the Institute.
Immune System Regeneration – Depleting myeloid-biased HSCs in aged mice restores features of a more youthful immune system.
Gasdermin in Pyroptosis – Gasdermin D N-terminal domain palmitoylation controls gasdermin membrane localization and activation.
Antibody-Drug Conjugates for Cancer – Scientists developed an antibody–drug conjugate that could kill TRBC1+ cancer cells in vitro and cure human T cell cancers in mouse models.
Hemorrhagic Fever Cell Receptors – The low density lipoprotein receptor is critical for the Crimean–Congo hemorrhagic fever virus to enter host cells.
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