The Fellow on Call: The Heme/Onc Podcast Episode 106: Colorectal Cancer Series, Pt. 8 - Early Onset Colorectal Cancer
Jun 19, 2024
Dr. Chris Cann, an Assistant Professor at Fox Chase Cancer Center, shines a light on the alarming rise of early onset colorectal cancer among younger individuals. He discusses the urgent need for awareness, highlighting genetic, environmental, and social factors contributing to this trend. The conversation also delves into the unique challenges faced by young adults with cancer, including psychosocial and fertility issues. With a blend of serious insights and light-hearted banter, Dr. Cann's expertise offers vital knowledge in this rapidly emerging area of oncology.
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Rising Incidence of Early Onset CRC
- Early onset colorectal cancer (CRC) incidence is rising sharply, especially rectal cancer among 20-34 year olds.
- Most early onset CRC cases are sporadic, with only 12-16% having pathogenic genetic variants.
Recognize Early Symptoms Quickly
- Blood in the stool, fatigue, and abdominal pain are common in early onset colorectal cancer.
- Prompt medical attention for these symptoms is critical, as many patients delay seeking care.
Microbiome and Lifestyle Factors
- Obesity and antibiotic exposure associate with increased risk of early onset colorectal cancer.
- Changes in the gut microbiome and diet-driven inflammation likely contribute to rising incidence.