LONGEVITY with Nathalie Niddam #360: How Liz Parrish Is REWRITING the Rules of Aging (Gene Therapy, Telomeres & The Future of Longevity)
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Aug 12, 2025 
In this engaging discussion, Liz Parrish, a trailblazer in longevity science and the first patient to experiment with innovative gene therapies, shares her inspiring journey. Motivated by her son's diagnosis with type 1 diabetes, she explores the transformative potential of gene therapy for aging. Topics include the biology of telomeres, the challenges of gene therapy delivery, and ethical concerns surrounding pediatric treatments. Liz also reflects on the importance of public perception and accessibility to these groundbreaking advancements, offering insights into practical longevity habits.
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From Stem Cell Advocate To Genetics
- Liz Parrish moved from stem cell advocacy to genetics after her son's diagnosis motivated her to seek curative strategies.
- She leveraged advocacy experience to accelerate translational approaches for childhood diseases.
Gene, Stem Cell, And Exosome Roles
- Liz Parrish distinguishes gene therapy, stem cells, and exosomes as different tools with different goals and persistence profiles.
- Gene therapy replaces gene function, stem cells rebuild tissue, and exosomes transmit repair signals.
Stem Cells Are The Repair Crew
- Liz emphasizes stem cells are the body's repair crew and decline dramatically with age, limiting regeneration.
- Reprogramming and returning stem cell numbers can restore youthful repair capacity.
