Research on IL-33's role in combats against skin-penetrating helminths reveals its significance in maintaining barrier integrity through gamma delta T cells. The loss of IL-33 in knockout mice resulted in their inability to resist these infections, suggesting that this interleukin is crucial for activating genes that support skin integrity. The findings underscore the important interaction between immune signaling and tissue barrier function, shedding light on potential therapeutic targets for enhancing resistance to helminth infections. This work exemplifies how understanding cellular responses can inform strategies to mitigate parasitic infections.
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, the annual meeting of the American Association of Immunologists in Chicago, and recorded daily episodes discussing highlights of the previous 24 hours. Here is the third of five special episodes from the meeting. Brenda and Jason spotlight discussions on cellular responses of microbial and parasitic infection and the immunology of pregnancy with a focus on glycan regulation of fetomaternal tolerance.