Plain English with Derek Thompson

Would You Buy a Drug to Extend Your Dog’s Life?

Feb 16, 2024
Celine Halioua, CEO and founder of Loyal, is on a mission to extend the lives of our furry companions with groundbreaking biopharmaceuticals. The discussion dives into her innovative drug, LOY-1, which slows aging in large dog breeds and hints at possible benefits for humans. Celine shares insights on the intriguing link between dog size and lifespan, along with the ethical dynamics of life extension. Plus, she sheds light on the unique challenges her biotech company faces in the pet health market.
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ANECDOTE

Dog Lover in Oaxaca

  • Celine Halioua, Loyal's CEO, is a dedicated dog lover currently in Oaxaca.
  • She's tempted to adopt senior street dogs, highlighting her passion for canine well-being.
INSIGHT

Dog Size and Lifespan

  • Larger dog breeds have shorter lifespans than smaller breeds, sometimes by a factor of two.
  • This difference, linked to growth hormone IGF-1, is unusual across species.
INSIGHT

Unintentional Breeding Consequences

  • Breeding for size in dogs unintentionally affected IGF-1 levels, impacting lifespan.
  • Loyal aims to mitigate these effects with its drug, LOY-1.
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