Talking Sleep

Tirzepatide & OSA: Implementation for Sleep Clinics

4 snips
Mar 21, 2025
Dr. Atul Malhotra, lead investigator of the SURMOUNT-OSA trial, joins specialists Dr. Radhika Breaden, Dr. Jeremy McConnell, and Dr. Rafael Sepulveda Acosta to discuss the groundbreaking FDA approval of tirzepatide for obstructive sleep apnea. They delve into its effectiveness beyond weight loss, practical implementation strategies for clinics, and the importance of managing associated conditions like obesity. The team addresses concerns about GLP-1 medications and emphasizes collaboration between sleep and obesity medicine to provide comprehensive care for patients.
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INSIGHT

SURMOUNT-OSA Trial Results

  • The SURMOUNT-OSA trial showed 50-60% AHI improvement in moderate to severe OSA patients using tirzepatide.
  • Patients also experienced notable weight loss, blood pressure reduction, and symptom relief.
ADVICE

Documentation for Insurance Approval

  • Document baseline AHI ≥ 15 and BMI for insurance approval of tirzepatide.
  • Include family history and a letter of medical necessity for smoother prior authorization.
ADVICE

Baseline Labs Before Starting Treatment

  • Order baseline labs like CBC, CMP, TSH, lipid panel, and A1C before starting tirzepatide.
  • Monitor kidney function especially in patients prone to dehydration or chronic kidney disease.
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