1) Cost-effectiveness of disease-modifying therapy and 2) Topic of the month: Mononeuropathies. This podcast for the Neurology Journal begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Mark Keegan with Dr. Katia Noyes about her paper on disease-modifying therapy for multiple sclerosis. In the next segment, Dr. Jennifer Fugate is reading our e-Pearl of the week about numb chin syndrome. In the next part of the podcast Dr. Ted Burns interviews Dr. John Stewart about peroneal neuropathy. In concluding, there is a brief statement where to find other up-to date patient information and current Patient Page. The participants had nothing to disclose except Drs. Keegan, Noyes, Fugate and Burns.Dr. Noyes serves on the scientific review panel for the National Multiple Sclerosis Society (NMSS) and has received research support from Biogen Idec, Boston Scientific, the NIH, and the NMSS.Dr. Keegan serves as a Section Editor for Neurology® and as Chief Editor for eMedicine; and has served as a consultant for Novartis and the FDA.Dr. Fugate serves on the editorial team for the Neurology® Resident and Fellow Section. Dr. Burns receives a stipend as Podcast Editor for Neurology®; performs EMG studies in his neuromuscular practice (30% effort); and has received research support from the Myasthenia Gravis Foundation of America and Knopp Neurosciences Inc..