The Internet Book of Critical Care Podcast IBCC Episode 91 - Catastrophic Antiphospholipid Syndrome
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Jul 22, 2020 AI Snips
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Complexity of Antiphospholipid Syndrome
- Antiphospholipid syndrome is complex with antibodies causing hypercoagulability despite prolonged PTT in vitro.
- It's an immune-driven thrombotic condition with varying antibody behavior and presentations.
Complement Driven CAPS Pathophysiology
- CAPS stems from antiphospholipid antibodies plus a trigger activating dysregulated complement and microvascular thrombosis.
- This vicious cycle causes multi-organ ischemia and failure, representing the catastrophic end of a spectrum.
Recognizing CAPS Patient Population
- Consider CAPS not only in lupus but also in isolated antiphospholipid antibody syndrome patients.
- Recognize classic multi-organ failure with renal, respiratory, neurologic, cardiac, and distinctive skin manifestations like digital gangrene.