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A deficiency in vitamin B6 can result in various symptoms and effects that are often overlooked. In addition to the commonly known symptoms such as rashes around the nose and mouth, pink eye, and neurological problems like numbness in the hands and feet, there are several other significant issues associated with B6 deficiency. These include inflammation, which is particularly relevant to gut inflammation and is highly correlated with low B6 levels; the inability to effectively metabolize polyunsaturated fatty acids, leading to dermatitis rashes; a negative impact on neurotransmitter production, potentially affecting mood, addiction, and overall nerve communication; difficulty converting ALA to DHA, a crucial omega-3 fatty acid, which may contribute to increased inflammation; impaired effectiveness of selenium, which can result in various deficiencies and enzyme-related problems; hindered conversion of tryptophan into niacin; interference with amino acid functions, such as contributing to hair loss and a higher risk of seizures; and insufficient homocysteine regulation, which can negatively impact heart health. Additionally, B6 deficiency can exacerbate symptoms of autism, particularly in individuals with compromised gut microbiomes. It is important to note that B6 deficiency is not solely diet-related, as factors such as antibiotic use, certain medications, alcohol consumption, smoking, and exposure to herbicides can also contribute to deficiency.