Boundless Life Modafinil: Is This Wildly Popular Smart Drug Safe And Effective? (& What It Can Do For Your Sleep Cycles & Brain Health).
Aug 27, 2020
Dr. Jonathan Wisor, a sleep researcher and neuroscientist from Washington State University, dives into the fascinating world of modafinil, the popular cognitive enhancer. They discuss how modafinil can boost alertness, improve mood, and enhance decision-making without significant side effects. Wisor shares insights on its influence on sleep cycles and neurotransmitters, cautioning against potential risks. The podcast also touches on personal experiences with modafinil in real-world scenarios, highlighting the fine balance between cognitive enhancement and sleep health.
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Modafinil Mechanism of Action
- Modafinil is a small molecule therapeutic that enters the brain and binds to dopamine transporters.
- This action blocks dopamine reuptake, enhancing motivational states and focus.
Modafinil's effect on neurotransmitters
- Modafinil indirectly affects norepinephrine, histamine, and orexin, neurotransmitters associated with arousal and attention.
- This broader impact contributes to its cognitive-enhancing effects.
Neuroprotective Effects
- Modafinil's neuroprotective effect is primarily relevant to those exposed to MPTP, a toxin found in impure synthetic opioids.
- It blocks the dopamine transporter, preventing MPTP uptake and subsequent cell death.