This Podcast for the Neurology Journal begins with Dr. John H. Noseworthy, Editor-in-Chief briefly discussing highlighted articles from the print issue of Neurology. In the second segment Dr. Mark Freedman & Dr. Ellis Hedaya interview Dr. Peter Calabresi from John Hopkins University about his paper on anti-natalizumab antibodies. The podcast concludes with Dr. Robb M. Snider interviewing Dr. James J. Lah for the Lesson of the Week. Podcast participants had nothing to disclose except for Dr. Peter Calabresi whohas received grant support in excess of $10,000 from Biogen Idec for other research/activities not reported in this article and honoraria from Biogen Idec in excess of $10,000/year. The statements presented in this podcast do not necessarily reflect those of the American Academy of Neurology or the Editors of the Journal Neurology.