What's Up Docs? Can psychedelics improve your mental health?
Sep 30, 2025
Dr. James Rucker, a consultant psychiatrist at King's College London, is leading groundbreaking trials on psilocybin for treatment-resistant depression. He explains how psychedelics stimulate serotonin receptors, offering insights into their potential therapeutic effects. Rucker details the structure of psilocybin therapy, emphasizing the profound benefits patients report, such as improved mood and lasting remission. The discussion also touches on the fine balance of using psychedelics respectfully within cultural contexts and cautioning recreational use.
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Cat Loss Led To Mouse Invasion
- Chris describes how his cat Winston's death unexpectedly led to a mouse infestation in the house.
- He jokes about naming the mice and debates pest control, mixing dark humour with worry about disease risks.
Baggage Complicates Psychedelic Research
- Psychedelics create strong cultural baggage that complicates objective medical evaluation.
- The hosts stress separating historical, recreational and clinical uses to assess evidence clearly.
Common Pharmacology Explains Psychedelic Effects
- Psychedelics share pharmacology by stimulating the serotonin 2A receptor, producing altered conscious states.
- James Rucker notes effects range from hallucinations to deeply meaningful or mystical experiences.