The Performance Nutrition Podcast

S9E10: Athlete Immunity: 6 Key Factors to Control w Prof. Michael Gleeson, PhD

4 snips
Nov 28, 2025
Professor Michael Gleeson, PhD, exercise immunologist from Loughborough University, brings decades of research on exercise, nutrition and immune function. He outlines six main factors that lower athlete immunity. He covers vitamin D testing and dosing, carbs and protein for immune support, roles of iron/zinc/selenium, sleep needs, probiotics and exercise’s anti-inflammatory effects.
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INSIGHT

Key Minerals Directly Influence Viral Control

  • Minerals like zinc, iron and selenium directly affect viral replication and immune tolerance.
  • Zinc can inhibit viral replication; zinc lozenges shorten cold duration and iron loss risks female athletes.
INSIGHT

Resistance Versus Tolerance Explains Disease Severity

  • Distinguish immune resistance (preventing/clearing infection) from immune tolerance (limiting damage from inflammation).
  • Excessive pro-inflammatory responses cause tissue damage as seen in severe COVID lung injury.
INSIGHT

Excess Fat Drives Pro‑Inflammatory Priming And Risk

  • Metabolic health and excess adipose tissue prime pro-inflammatory responses and worsen infection outcomes.
  • Enlarged fat cells attract immune cells that produce cytokines, raising baseline inflammation before infection.
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