59. Skin Cancer, UV Light & All-Cause Mortality | Prof. Richard Weller
Mar 2, 2024
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Dermatologist Prof. Richard Weller discusses how increased UV light is linked to lower mortality rates and highlights the benefits of sunlight in improving cardiovascular and overall health. The conversation challenges sun-phobic narratives, explores skin physiology, skin protection mechanisms, UV exposure patterns, melanoma risks, vitamin D levels, and the non-vitamin D benefits of sunlight on health. They also touch on nitric oxide release from the skin, immune system effects, and mortality outcomes related to sun exposure.
Increased UV light is linked to lower mortality rates, including cardiovascular and cancer mortality.
Sun exposure benefits extend beyond skin health to reduce risks of cardiovascular and autoimmune diseases.
Skin color influences optimal sunlight exposure, impacting survival advantages in low-light environments.
Deep dives
Regenerate Allbury Health Summit
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Sunlight and Skin Health Insights
The podcast delves into the relationship between sunlight, skin health, and conditions like melanoma. Professor Richard discusses the skin's protective mechanisms against UV damage, shedding light on DNA mutations, repair processes, and the role of melanin. Contrary to common beliefs, balanced sunlight exposure is associated with reduced risks of cardiovascular, cancer, and autoimmune diseases. The discussion highlights the importance of understanding skin physiology and adapting sun exposure behaviors to optimize health outcomes.
Skin Color and Sunlight Optimal Exposure
Skin color plays a crucial role in determining the optimal amount of sunlight exposure for an individual, impacting their survival advantage and evolutionary fitness in low-light environments. This emphasizes the importance of considering skin color when assessing sunlight exposure benefits.
Risk-Benefit Analysis in Sun Exposure
Physicians, including dermatologists, often focus solely on the risks associated with sun exposure, such as melanoma, while overlooking the broader health benefits like reduced cardiovascular mortality. By neglecting the overall risk-benefit analysis, there may be instances of overdiagnosis and potentially missing out on the positive effects of sunlight on various health conditions beyond just skin diseases.
Professor Richard Weller is a UK dermatologist, researcher and world expert on the effect of ultraviolet (UV) light on systemic health. We discuss sunlight, skin cancer and the profound findings of large population-based studies that greater ultraviolet (UV) light and sunlight exposure is associated with greater longevity and less chronic disease.
Prof. Weller's discovery of nitric oxide (NO) release in the skin on UV-A exposure was pivotal in understanding the cardiovascular benefits of sunlight.
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LINKS Prof Weller bio - https://www.ed.ac.uk/inflammation-research/people/principal-investigators/professor-richard-weller
Higher ultraviolet light exposure is associated with lower mortality: an analysis of data from the UK Biobank cohort study - https://www.medrxiv.org/content/10.1101/2023.07.11.23292360v1
Avoidance of sun exposure is a risk factor for all-cause mortality: results from the Melanoma in Southern Sweden cohort - https://onlinelibrary.wiley.com/doi/10.1111/joim.12251
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