Big Questions with Cal Fussman

Learning From Weight Loss Drugs

Apr 22, 2025
Discover the revolutionary impact of GLP-1 drugs on weight loss and appetite control. Listen in as Cal shares his personal journey with these medications, uncovering how they help recalibrate brain signals to shift from craving more to feeling satisfied with less. Explore the connection between overeating, the brain's reward system, and how these new solutions could transform our relationship with food. It's a candid look at hunger, health, and even the joy of stopping after just one bite!
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ANECDOTE

Cal's Drug-Averse Journey

  • Cal Fussman avoided drugs and pharmaceuticals for most of his life due to personal and family reasons.
  • He only started reconsidering after assembling a medical team and noticing weight gain in his later years.
INSIGHT

Brain's "More, More, More" Loop

  • Modern lifestyle changes trick our brains into craving more food and storing more fat unnecessarily.
  • This brain message drives overeating and obesity in 75% of American adults.
INSIGHT

Brain's Reward System Hijacked

  • The brain's reward system gets hijacked by hyper-palatable foods triggering dopamine surges.
  • This causes a habit loop making it hard to stop eating, even when the stomach signals fullness.
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