Big Questions with Cal Fussman

A high school student named Matteo Paz uses old NASA data and new AI to find 1.5 million objects never noticed before in space (including planets in other solar systems). AI can now predict 130 diseases (including heart ailments, kidney failure and strokes) based on studying one night of sleep. And a school called Alpha uses only AI tutors, teaches core academics for only two hours a day and achieves top scores. Don't be late for the future.

In the age of artificial intelligence, it isn't a machine that stops Cal in his tracks—it's a deeply human idea. What if playing a video game could help fight cancer? Thanks to Travis Jennings and a small group of friends, a chain reaction begins—turning gamers with little money of their own into philanthropists. A breakout company called Besitos matches their winnings with donations to the American Cancer Society and bridges the cause to the $60 billion video game industry.

Imagine a mind that can solve a Rubik's Cube in 17 seconds. A mind that contributed to the development of OpenAI. A mind that directed AI for Elon Musk at Tesla. A mind named one of Time Magazine's Top 100 in artificial intelligence. Now imagine that same mind encountering recent, almost "alien" advances in programming—so startling they prompted a public admission: "I have never felt so behind." If someone like that can't keep up, what does it mean for the rest of us? We're entering a world we may not soon recognize. For Cal, that realization leads to a simple conclusion: This New Year isn't about racing machines—it's about reclaiming what they can't replace.

When Cal visits an old mentor, he's struck by two realizations. First: Some of the most profound moments in a young person's life can happen in entry-level jobs, when the right person takes you in, opens a door, and points you on the right path. Second: As artificial intelligence wipes out many of those first jobs, it will also erase those connections and moments. What disappears isn't just work. It's mentorship. It's the quiet bonds that shape confidence, character, and destiny. What will happen to a generation shaped without them? And an even bigger question: How might we be able to preserve them?

There are those believe artificial intelligence will cure cancer, reverse global warming, and unlock human potential. There are others who believe it will end everything we know. For the first time in history, both sides may be right. We are living inside the most consequential argument humanity has ever had — and the clock is ticking.

When Cal returns to Tampa's Ybor City to speak, he keeps a ritual that's become almost sacred: a meal at the legendary 120-year-old Columbia Restaurant, followed by a quiet moment of thanks to the man who first sent him there — Muhammad Ali's doctor, the renowned Ferdie Pacheco. Ferdie wasn't just the "Fight Doctor." He was an artist, a storyteller, and a man with a taste for a good practical joke. After his meal, Cal goes to pay tribute to Ferdie through his painting that hangs near The Columbia's kitchen. Only this time, the painting is gone, and it feels to Cal like an old friend has vanished. What happened next left Cal with a twist he couldn't see coming — and a hint that destiny sometimes whispers through the strangest openings. Listen in to hear the story unfold.

A Thanksgiving chat kicks off with concerns about AI and job security. Cal suggests looking back to childhood memories as a career compass. He shares stories of innovators like Clint Eastwood and Hank Aaron, who found their paths through early experiences. By reflecting on past passions, Cal argues, individuals can navigate an AI-driven job market. He emphasizes delivering value that goes beyond traditional resumes. Unexpected career pivots, like NVIDIA's shift from gaming to AI, demonstrate the possibilities that arise from embracing change.

The discussion kicks off with a mind-bending scenario of a human marrying an AI and the implications of such a union. A Japanese woman’s wedding to her AI, Loon Krauss, raises eyebrows as wedding planners see a new trend. Social media reactions range from humorous to concerned, highlighting societal shifts. Cal reflects on the allure of AI in love, contrasting it with traditional marriages. Statistics reveal a growing trend among young people seeking romance with AI, prompting reflections on future perceptions of human-only marriage.

When Cal looks back on his life, he sees a relentless drive that's guided him to his 69th birthday: Never be bored. His past reveals a simple truth. Boredom ends where curiosity begins.

Cal looks over a bountiful breakfast menu and remembers the statistics he heard about kids going hungry in Tampa Bay — a city that, through his traveler's eyes, appears to be flourishing. When you hear the numbers, you'll understand how giving just a little can make this your best Thanksgiving ever.