Are life-saving medicines hiding in the world's coldest places? | Normand Voyer
Dec 19, 2023
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Chemist Normand Voyer explores the mysterious molecular treasures found in plants thriving in the cold. These organisms hold immense medical promise. Researchers investigate and extract natural substances with potential antimalarial properties. The importance of preserving biodiversity in the coldest places on Earth is highlighted, along with ongoing efforts to search for new natural substances and medicines.
Organisms in the Arctic produce unique chemicals to protect themselves, which could hold immense medical promise
The Arctic's molecular treasures, such as Mortiamites, have the potential to provide solutions to global health challenges
Deep dives
Searching for Medical Solutions in the Arctic
Normand Voyi, a natural product chemist, explores the Arctic in search of peculiar fungi and lichens that may hold medical solutions. By studying the unique stresses and conditions faced by organisms in the Arctic, Normand believes that they produce chemicals to protect themselves. For example, lichens in the northern ecosystem have defense chemicals that efficiently block UV rays. Through careful research and analysis of lichens, Normand has discovered 13 natural substances, including two that are unique in the world. These findings open up new possibilities for drugs to treat diseases and inspire further research.
Discovering Antimalarial Compounds
In the sediment of the icy Frobisher Bay in Nunavut, a macroscopic fungus called Mortiarella was found to produce unique natural substances called Mortiamites. Researchers discovered that these compounds shared similarities with substances from African plants that had antimalarial properties. To test their effectiveness, an ample supply of Mortiamites was synthesized and studied, revealing their ability to neutralize malaria parasites, including drug-resistant strains. This discovery highlights the potential of natural substances from the Arctic to provide solutions to global health challenges.
The Urgency to Protect the Arctic's Biodiversity
The rapidly warming Arctic is causing significant changes to the region's ecosystems, including the greening of northern ecosystems and the expansion of shrubs, which disrupts the food chain and traditional ways of life for indigenous communities. Loss of biodiversity, including the disappearance of plants, lichens, and fungi, may result in the loss of unknown natural substances, potential wonder drugs. Therefore, the work of exploring and preserving the Arctic's molecular treasures becomes crucial in the face of climate change. It requires collective efforts to protect this unique environment and its potential contributions to global health.
Could the next wonder drug be somewhere in Canada's snowy north? Take a trip to this beautiful, frigid landscape as chemist Normand Voyer explores the mysterious molecular treasures found in plants thriving in the cold. These scarcely investigated organisms could hold immense medical promise, he says — so long as we work quickly enough to discover them.