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ImmunoTea: Your Immunology Podcast
ImmunoTea Episode 1 - IL-17 and Neurological Autoimmunity
Jan 9, 2023
In this fascinating discussion, distinguished immunologist Prof. Kingston Mills and neurological autoimmunity expert Dr. Anastasia Zekeridou dive deep into the powerful cytokine IL-17. They unpack its dual role in diseases like multiple sclerosis, emphasizing targeted therapies and potential risks of blocking IL-17. The guests also touch on the role of tissue-resident memory T cells and the implications of immune responses in paraneoplastic neurological syndromes. Their insights on antibody pathogenicity and the intersection of cancer treatment with neurological autoimmunity are truly enlightening.
50:30
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Quick takeaways
- IL-17 is a crucial cytokine in both immune response and autoimmune pathology, acting as a double-edged sword in various diseases.
- The interplay between cancer treatments and neurological autoimmunity underscores the need for predictive models to identify at-risk patients.
Deep dives
Understanding Interleukin 17's Dual Role
Interleukin 17 (IL-17) functions as both a protective and damaging cytokine, making it a significant focus in immunology research. Originally identified in multiple sclerosis patients, IL-17 is crucial for the immune response to fungal and bacterial infections, yet it also mediates pathology in various autoimmune diseases. The cytokine acts similarly to a double-edged sword, contributing to inflammation in conditions like psoriasis and ankylosing spondylitis while playing a protective role against infections. Recent studies underscore IL-17's potential as a therapeutic target, with several therapies now in use that specifically target IL-17 to treat autoimmune diseases.
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