The Optispan Podcast with Matt Kaeberlein

Doctor Reveals: The Dark Side of the Longevity Industry

Oct 15, 2025
Explore the intriguing contrasts between high-stakes investor gatherings and academic conferences in the longevity field. Discover the ethical dilemmas surrounding biological age clocks and hear a hilarious MRI tale from Berlin. Dive into insights about the divide between genuine science and snake oil remedies, and the challenges of translating geroscience into practical therapies. From promising biomarkers to the impact of celebrity culture, the conversation spotlights the complex landscape of longevity and health optimization.
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INSIGHT

Longevity Has A Growing Two‑World Problem

  • Matt observed a stark divide between investor/celebrity-driven longevity and academic geroscience after back-to-back conferences.
  • He argued this split risks credibility as hype can overshadow rigorous science and slow progress.
INSIGHT

Three Camps Shape The Field's Trajectory

  • Matt described three camps: hype-driven actors, apologists who welcome attention, and evidence-focused scientists.
  • He warned that apologists risk normalizing snake oil by valuing publicity over trust.
ADVICE

Don't Use Epigenetic Clocks Clinically Yet

  • Avoid using current biological age or epigenetic clocks in clinical care because their precision and accuracy are unknown.
  • Do not base medical decisions on tests without validated error rates and clinical validation.
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