JAMA Cardiology Author Interviews Preserving and Promoting Clinical Trial Representativeness
Jul 30, 2025
Roxana Mehran, a leading cardiologist at Mount Sinai, discusses the crucial need for diversity in clinical trials. She emphasizes that inclusivity improves patient care and treatment outcomes. The conversation covers strategies to enhance representation, such as community engagement and effective recruitment methods. Mehran highlights the industry's role in fostering diversity and the positive impact of transparent data reporting. Ultimately, she underscores that diverse trial populations are essential for developing reliable medical practices.
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Importance of Inclusive Trials
- Clinical trials must be inclusive and representative of the disease prevalence in the population.
- This ensures trial results can be implemented effectively in patient care to reduce cardiovascular disease burden.
Trial Design and Recruitment Tips
- Design trials by aligning inclusion criteria with disease prevalence across populations.
- Engage communities and address language and health literacy to improve recruitment and retention.
Value of Patient Engagement
- Include patient and community representatives on steering committees to build trust.
- This improves recruitment and aligns trial endpoints with patient priorities.