GLP-1 Side Effects, Longevity Science, Light as Medicine, and Fasting with Nathalie Niddam

In this episode of the Beautifully Broken Podcast, Freddie Kimmel is joined once again by Nathalie Niddam—nutritionist, biohacker, and creator of the Longevity and Peptide communities. The two dive into an honest and practical dialogue about what it really means to support the body in today’s world.

Freddie shares updates from his own journey, including building the Biological Blueprint Academy, his personal experience with GLP-2 microdosing, and how technologies like the Avacyn and blood flow restriction training fit into his healing toolbox. Nathalie explains the evolving science around GLP-1 agonists like semaglutide, the recent headlines linking them to vision issues, and why safe dosing and practitioner support are critical.

The conversation also explores:
• Why light is a foundational nutrient as important as food.
• How “stacking” therapies can either synergize or overwhelm the body.
• The importance of journaling and self-tracking when experimenting with peptides.
• The distinction between true foundational practices and enhancement technologies.
• Fasting as both a physiological and spiritual discipline.

This episode blends cutting-edge science, grounded health principles, and lived wisdom—reminding us that while peptides and devices can accelerate progress, they will never replace the basics: movement, environment, light, sleep, and community

Episode Highlights

[00:00] – The risks uncovered: Dramatic drops in glucose and weight, and the rare but serious possibility of optic‑nerve damage with GLP‑1s.
[01:16] – Freddie’s health update and the surprising wellness wins worth celebrating.
[04:47] – Nathalie on environmental overload, “stacking” inputs, and tuning into body signals.
[06:16] – The energetic layers behind biohacking—and what happens when you’re too sensitive.
[10:01] – Building Peptide Parlor, fostering a longevity-minded community, and embracing collaboration.
[11:53] – Supplement overwhelm, industry bias, and the importance of prioritizing body signals over protocol.
[22:08] – Reframing GLP-1 use: sustainable weight loss, psychological shifts, and the pace your body prefers.
[35:49] – Understanding semaglutide, tirzepatide, and red-atrutide—and why more isn’t always better.
[45:10] – Blood flow restriction, Avacyn, vibration, and microcirculation: stacking devices with intention.
[51:29] – Fasting mimetics vs. true fasting: metabolic benefits, risks, and the deeper layers beyond restriction.
[56:01] – Nathalie’s peptide story: CJC/Ipamorelin, mast cells, histamine flares, and learning what not to do.
[01:10:56] – Stem cells, exosomes, Therium testing, and how to track longevity with real biomarkers.

Links & Resources

Nathalie Niddam’s website/membership community: https://www.natniddam.com/

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CONNECT WITH FREDDIE

Work with Me: https://www.beautifullybroken.world/biological-blueprint

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