Ever since the book "Lifespan" came out from Dr David Sinclair, everyone and their dog and has been supplementing with nicotinamide mononucleotide and nicotinamide riboside and an effort to increase our levels in the body.NAD is essential to life. No energy production can happen without NAD. NAD Also decreases as we age so the question has always been should we and can we increase our NAD levels.

As usual in biology it's very complicated and as the science has developed we have learned many new detailed insights.

Here is an update on the latest in that science.

In this episode of "Pushing The Limits" I have the wonderful privilege of interviewing one of the world's leading researchers in NAD metabolism, sirtuin genes and metabolic health Professor Joseph Baur.

Professor at the Perelman School of Medicine of the University of Pennsylvania,

How can you increase NAD+ levels? And do higher NAD+ levels really lead to better metabolic health? What does the research say on their benefits for Longevity.

We cover this critical pathway in-depth looking what the research is saying and what it currently isn't and what we have still to learn.
We look into mice studies and then also where the human research is at.
We cover the salvage pathway as well as the Preiss Handler pathway.
The possible role of the Microbiome and in NAD metabolism.
We also discussed the various NAD pools and why the mitochondria maybe a key in a NAD pool.
We discuss the transporter for NAD into the mitochondria that was recently discovered by Prof Baur and other labs.
We discuss also the possible risk factors and how we can mitigate these.
We look at where the research is at in relation to cancer and NAD Metabolism.
The role of CD 38 as a voracious consumer of in NAD and how lowering CD38 in the body may be even more beneficial than taking the precursor enzymes.
We discuss also why CD38 increases as we age and what we can do about it and the role of senolytics.
How we can increase the NAMPT enzyme so we recycle more of our NAD And whether we need to support our methylation donors when we are supplementing with the likes of NMB and NR.

If you are fascinated by longevity science and want to know how you can optimise your health moving forward then this is the episode for you!

Want to try NMN, TMG and quercetin to support your healthy NAD metabolism you can find them in my shop

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Lisa and team

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